PLAB Practice Exam 2026 – The Complete Guide to Mastering the Professional and Linguistic Assessments Board Test!

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Which antibodies are commonly found in Hashimoto's thyroiditis?

Anti-TPO (thyroid peroxidase)

In Hashimoto's thyroiditis, the primary antibodies that are characteristically elevated include anti-thyroid peroxidase (anti-TPO) antibodies. The presence of these antibodies is significant because they target the enzyme thyroid peroxidase, which is crucial for synthesizing thyroid hormones. High levels of anti-TPO antibodies are indicative of autoimmune activity against thyroid cells and are commonly used in clinical practice as biomarkers for Hashimoto's thyroiditis.

While both anti-thyroglobulin and anti-microsomal antibodies can also be present in Hashimoto's thyroiditis, the most specific and commonly tested antibody associated with this condition in a variety of settings is anti-TPO. The anti-TSH receptor antibodies are more typically seen in Graves' disease, another autoimmune thyroid condition, emphasizing the difference in antibody profiles associated with specific thyroid disorders.

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Anti-thyroglobulin

Anti-TSH receptor

Anti-microsomal

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