Professional and Linguistic Assessments Board (PLAB) Practice Exam

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What is the pre-treatment for MRSA colonization?

Nasal mupirocin and Chlorhexidine for skin
Vancomycin and Clindamycin for skin
Trimethoprim and Sulfamethoxazole
Metronidazole and Doxycycline

The correct answer is: Nasal mupirocin and Chlorhexidine for skin

The recommended pre-treatment for MRSA (Methicillin-resistant Staphylococcus aureus) colonization typically includes nasal mupirocin along with chlorhexidine for skin decontamination. Mupirocin is an antibiotic effective specifically against Staphylococcus species and is used intranasally to eliminate nasal colonization of MRSA. Likewise, chlorhexidine is an antiseptic used for skin cleansing, effectively reducing the overall bacterial load on the skin and further decreasing the risk of developing infections. The combination of these two treatments targets MRSA at the sites where it most often colonizes (the nasal passages and skin), providing a comprehensive approach to pre-treatment before surgical procedures or in high-risk patients. This protocol helps to minimize the risk of MRSA infections in both community and healthcare settings. The other options listed are not traditionally recommended for pre-treatment of MRSA colonization in the same effective manner that mupirocin and chlorhexidine are.