Professional and Linguistic Assessments Board (PLAB) Practice Exam

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What is the recommended treatment for dysmenorrhea in young, non-sexually active females?

Mefenamic acid
Ibuprofen
Acetaminophen
Aspirin

The correct answer is: Mefenamic acid

Mefenamic acid is a nonsteroidal anti-inflammatory drug (NSAID) that is particularly effective in treating dysmenorrhea, which is pain related to menstruation. It functions by reducing pain and inflammation through the inhibition of prostaglandin synthesis. In young, non-sexually active females, who may present with primary dysmenorrhea, mefenamic acid can be particularly beneficial as it provides both analgesic and anti-inflammatory effects, making it a preferred first-line treatment. While other options like ibuprofen are effective NSAIDs as well, mefenamic acid is specifically indicated for menstrual pain in this demographic. Acetaminophen, while useful for pain relief, does not target inflammation as effectively as NSAIDs, and aspirin, although it has anti-inflammatory properties, is not routinely recommended for dysmenorrhea due to its potential side effects and the risk of Reye syndrome in younger patients. Therefore, mefenamic acid stands out as the most recommended treatment for young, non-sexually active females experiencing dysmenorrhea.